Cancer treatment runs in parallel with advanced scientific research. FICAN West is the second largest cancer research center in Finland. Its mission is to coordinate cancer research and teaching in the entire West-coast area.
We promote cancer research and the use of up-to-date scientific data within FICAN West and in the whole of Finland.
The Turku Clinical Research Center provides services in the field of health scientific research for researchers of the University of Turku and the Turku special responsibility area.
This takes you to the web page of the Turku Clinical Research centre
Glossary
Special terms are needed when clinical trials are discussed. Laaketutkimukset.fi-website (in Finnish) contains explanations of the most common terms used in clinical trials.
| STUDY CENTER AND PRINCIPAL INVESTIGATOR | STUDY CODE | TITLE OF THE STUDY |
|---|
| GYNECOLOGICAL CANCER | ||
|---|---|---|
| TUCH / Sakari Hietanen | DOVACC | A Randomized Clinical Trial Investigating Olaparib, Durvalumab (MEDI4736) and UV1 as Maintenance Therapy in BRCAwt Patients with Recurrent Ovarian Cancer |
| LYMPHOMA | ||
|---|---|---|
| TUCH / Sirkku Jyrkkiö | POLAR BEAR | R-MINI-CHOP versus R-MINI-CHP in combination with polatuzumab-vedotin, as primary treatment for patients with diffuse large B-cell lymphoma, ≥80 years, or frail ≥75 years |
| TUCH / Taina Reunamo | FirmMind | A Phase 3, Single-Arm, Open-Label, Multicenter Study to Evaluate the Safety and Efficacy of Tafasitamab Plus Lenalidomide in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma |
| BREAST CANCER | ||
|---|---|---|
| Vaasa Central Hospital / Antti Jekunen | CO41101 | A Phase III, Double-blind, Placebo-controlled, Randomized Study Of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer |
| TUCH / Riikka Huovinen | lidERA | A PHASE III, RANDOMIZED, OPEN-LABEL, MULTICENTER STUDY EVALUATING THE EFFICACY AND SAFETY OF ADJUVANT GIREDESTRANT COMPARED WITH PHYSICIAN’S CHOICE OF ADJUVANT ENDOCRINE MONOTHERAPY IN PATIENTS WITH ESTROGEN RECEPTOR POSITIVE, HER2-NEGATIVE EARLY BREAST CANCER |
| BLADDER CANCER | ||
|---|---|---|
| TUCH / Peter Boström | FINNBLADDER 9 | Treatment of stage Ta cancer of the urinary bladder with a high risk of relapse – blue-light cystoscopy and optimized dosage of mitomycin-C. |
| TUCH / Peter Boström | FINNBLADDER 10 | Intravesical Instillation Therapy With Bacillus Calmette-Guérin (BCG) and Sequential BCG and Electromotive Mitomycin-C (EMDA-MCC) in Patients With High-risk Non-muscle-invasive Bladder Carcinoma. |
| TUCH / Peter Boström | MK-3475-057 | A Phase II Clinical Trial to Study the Efficacy and Safety of Pembrozizumab (MK-3475) in Subjects with High Risk Non-Muscle Invasive Bladder Cancer (NMIBC) Unresponsive to Bacillus Calmette-Guerin (BCG) Therapy |
| RENAL CANCER | ||
| TUCH / Kalle Mattila | MK-6482-022 | A Multicenter, Double-blind, Randomized Phase 3 Study to Compare the Efficacy and Safety of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab, in the Adjuvant Treatment of Clear Cell Renal Cell Carcinoma (ccRCC) Post Nephrectomy |
| PROSTATE CANCER | ||
| TUCH / Peter Boström | SPCG-15 | Surgery or radiation therapy in the treatment of locally advanced prostate cancer – open, randomized clinical trial. |
| TUCH / Peter Boström | TALAPRO-3 | A PHASE 3, RANDOMIZED, DOUBLE-BLIND, STUDY OF TALAZOPARIB WITH ENZALUTAMIDE VERSUS PLACEBO WITH ENZALUTAMIDE IN MEN WITH DDR GENE MUTATED METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER |
| TUCH / Peter Boström | HIFU-PRO-BPH | A early phase 1 non-randomized prospective single-institutional and four arm study to determine the applicability, feasibility and safety of MRI guided transurethral HIFU ablation of prostate separately in each pre-specified group/arm |
| TUCH / Jukka Kemppainen | ADTPSMA2 | The Effect of Androgen Deprivation Therapy on the Expression of Prostate Specific Membrane Antigen (PSMA) Evaluated With 18F-PSMA PET/CT in Treatment naïve Metastatic Prostate Cancer Patients |
| TUCH / Otto Ettala | ESTO-2 | Impact of atorvastatin on prostate cancer progression after initiation of androgen deprivation therapy- lipid metabolism as a novel biomarker to predict prostate cancer progression – Phase 3, double-blind randomized clinical trials FinnProstata XV |
| HEAD AND NECK CANCER |
|---|
| HEMATOLOGICAL CANCER | ||
|---|---|---|
| TUCH / Mervi Putkonen | MagnetisMM-5 | Study of Elranatamab (PF-06863135) Monotherapy and Elranatamab + Daratumumab Versus Daratumumab + Pomalidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma |
| TUCH / Mervi Putkonen | MagnetisMM-7 | Study With Elranatamab Versus Lenalidomide in Patients With Newly Diagnosed Multiple Myeloma After Transplant |
| TUCH / Mervi Putkonen | Excaliber-RRMM | Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) |
| TUCH / Juha Ranti | Cartitude-5 | A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy |
| MELANOMA |
|---|
| GASTROINTESTINAL CANCER | ||
|---|---|---|
| Satasairaala Hospital / Kalevi Pulkkanen | SSGXXII | Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST With a High Risk for Recurrence |
| TUCH / Pirita Varpe | RESET | Laparotomy vs Laparoscopy vs Robotic vs TaTME Rectal Surgery Matched Parallel Cohort Trial for High Surgical Risk Cancer Patients, With Mid- to Low Rectal Cancer |
| TUCH / Raija Ristamäki
Vaasa Central Hospital / Pia Österlund | BREAKWATER | AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST-LINE ENCORAFENIB PLUS CETUXIMAB WITH OR WITHOUT CHEMOTHERAPY VERSUS STANDARD OF CARE THERAPY WITH A SAFETY LEAD-IN OF ENCORAFENIB AND CETUXIMAB PLUS CHEMOTHERAPY IN PARTICIPANTS WITH METASTATIC BRAF V600E-MUTANT COLORECTAL CANCER |
| TUCH / Raija Ristamäki | KRYSTAL | A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy |
| HEPATOCELLULAR CARCINOMA | ||
|---|---|---|
| TUCH / Eetu Heervä | IMBrave251 | A PHASE III, OPEN-LABEL, RANDOMIZED STUDY OF ATEZOLIZUMAB WITH LENVATINIB OR SORAFENIB VERSUS LENVATINIB OR SORAFENIB ALONE IN HEPATOCELLULAR CARCINOMA PREVIOUSLY TREATED WITH ATEZOLIZUMAB AND BEVACIZUMAB |
| LUNG CANCER | ||
|---|---|---|
| TUCH / Maria Silvoniemi and Vaasa Central Hospital / Antti Jekunen | ASTEROID | Ablative STEreotactic RadiOtherapy wIth Durvalumab (MEDI4736). An Open Label Randomized Phase II Trial With Durvalumab Following Stereotactic Body Radiotherapy (SBRT) in Patients With Stage I Non-small Cell Lung Cancer (NSCLC) |
| TUCH / Maria Silvoniemi | DART | A study of Durvalumab, a type of immunotherapy, for treatment of patients with non-small cell lung cancer with positive or negative PD-L1 expression, following chemotherapy and radiotherapy |
| TUCH / Maria Silvoniemi | KontRASt-02 | Study of JDQ443 in Comparison With Docetaxel in Participants With Locally Advanced or Metastatic KRAS G12C Mutant Non-small Cell Lung Cancer |
| TUCH / Maria Silvoniemi | LUNG 213824 | A Phase 2, Randomized, Open-label, Platform Study Utilizing a Master Protocol to Evaluate Novel Immunotherapy Combinations in Participants with Previously Untreated, Locally Advanced/Metastatic, Programmed Death Ligand 1-Selected Non-Small-Cell Lung Cancer |
| TUCH / Maria Silvoniemi | COSTAR Lung | A RANDOMIZED, OPEN-LABEL PHASE 2/3 STUDY COMPARING COBOLIMAB + DOSTARLIMAB + DOCETAXEL TO DOSTARLIMAB + DOCETAXEL TO DOCETAXEL ALONE IN PARTICIPANTS WITH ADVANCED NON-SMALL CELL LUNG CANCER WHO HAVE PROGRESSED ON PRIOR ANTI-PD-(L)1 THERAPY AND CHEMOTHERAPY |
| OTHER | ||
|---|---|---|
| TUCH / Kalle Mattila | PD-1 Heart | Predictive clinical, imaging and laboratory biomarkers of cardiac toxicity related to anti-programmed death (PD)-1 therapies |
| TUCH / Erika Alanne | FINPROVE | The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs to determine the Efficacy in Treatment of Advanced Cancers with a Known Molecular Profile |
| TUCH / Maria Sundvall | BIOURICA | Development of a biosensor to detect urine-based cancer biomarkers |
| PEDIATRIC | ||
|---|---|---|
| TUCH / Päivi Lähteenmäki | IntreALL 2010 HR | International Study for Treatment of High Risk Childhood Relapsed ALL 2010, A randomized Phase II Study Conducted by the Resistant Disease Committee of the International BFM Study Group |
| TUCH / Päivi Lähteenmäki | ALL Together | A Treatment study protocol of the ALLTogether Consortium for children and young adults (1-45 years of age) with newly diagnosed acute lymphoblastic leukaemia (ALL), |
| TUCH / Päivi Lähteenmäki | LBL 2018 | International cooperative treatment protocol for children and adolescents with lymphoblastic lymphoma |
| TUCH / Päivi Lähteenmäki | NHL 2013 | Treatment protocol of the NHL-BFM and the NOPHO study groups for mature aggressive B-cell lymphoma and leukemia in children and adolescents |
| TUCH / Miia Mokka | TEDDI | Radiotherapy Delivery in Deep Inspiration for Pediatric Patients |
| TUCH / Päivi Lähteenmäki | INFORM | INdividualized Therapy FOr Relapsed Malignancies in Childhood |
| TUCH / Anu Huurre | rEEcur | International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma |
| TUCH / Minna Koskenvuo | Evaluation of long-term Safety in Peadiatric With B-precursor Acute Lymphoblastic Leukemia (ALL) who Have Been Treated Either Bliunatumomab or Chemotherapy, Followed by Transplantation | |
| TUCH / Laura Korhonen | PeCCaPS | Personal Crisis and Cancer Predisposition Syndromes. |
| TUCH / Riikka Kuvaja and Päivi Lähteenmäki | PACS | Short and long-term consequences of pregnancy-associated cancer in women and their children. |
