Cancer treatment runs in parallel with advanced scientific research. FICAN West is the second largest cancer research center in Finland. Its mission is to coordinate cancer research and teaching in the entire West-coast area.
We promote cancer research and the use of up-to-date scientific data within FICAN West and in the whole of Finland.
The Turku Clinical Research Center provides services in the field of health scientific research for researchers of the University of Turku and the Turku special responsibility area.
This takes you to the web page of the Turku Clinical Research centre
Glossary
Special terms are needed when clinical trials are discussed. Laaketutkimukset.fi-website (in Finnish) contains explanations of the most common terms used in clinical trials.
| STUDY CENTER AND PRINCIPAL INVESTIGATOR | STUDY CODE | TITLE OF THE STUDY |
|---|
| GYNECOLOGICAL CANCER | ||
|---|---|---|
| TUCH / Sakari Hietanen | ENGOT –EN2-DGCG | Randomized multicenter trial on the risk of recurrence for patients with cancer limited to the uterus. After surgery, adjuvant treatment or follow-up. |
| TUCH / Sakari Hietanen | KEYNOTE-B21 (MK-3475-B21) | A Phase 3, Randomized, Double-Blind Study of Pembrolizumab versus Placebo in Combination With Adjuvant Chemotherapy With or Without Radiotherapy for theTreatment of Newly Diagnosed High-Risk Endometrial Cancer After Surgery With Curative |
| LYMPHOMA | ||
|---|---|---|
| TUCH / Sirkku Jyrkkiö | ENRICH | Randomised, open label study of Rituximab/Ibrutinib vs Rituximab/Chemotherapy in older patients with untreated mantle cell lymphoma |
| BREAST CANCER | ||
|---|---|---|
| TUCH/ Riikka Huovinen ja Vaasa Central Hospital / Antti Jekunen | BOLD | A randomized phase III study compairing trastuzumab,pertuzumab plus docetaxel (TPD) followed by 3 cycles of chemotherapy to the current standard regimen as the treatments of early HER2-positive breast cancer |
| TUCH/ Marjaana Luukkaa | SKAGEN | Moderately hypofractionated loco-regional adjuvant radiation therapy of early breast cancer combined with a simultaneous integrated boost in patients with an indication for boost |
| TUCH/ Pia Vihinen | IMpassion132 | A phase III, randomized, double-blind, placebo-controlled, multicentre study of the efficacy and safety of atezolizumab plus chemotherapy for patients with early relapsing recurrent triple-negative breast cancer |
| Vaasa Central Hospital / Antti Jekunen | CO41101 | A Phase III, Double-blind, Placebo-controlled, Randomized Study Of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Locally Advanced Unresectable or Metastatic Triple-Negative Breast Cancer |
| TUCH / Riikka Huovinen | Ameera | A randomized, multicenter, double-blind phase 3 study of SAR439859 plus palbociclib versus letrozole plus palbociclib for the treatment of patients with ER (+), HER2 (-) breast cancer who have not received prior systemic anti-cancer treatment for advanced disease |
| BLADDER CANCER | ||
|---|---|---|
| TUCH / Peter Boström | KEYNOTE-057 | Open clinical trial to assess the efficacy and safety of pembrolizumab (MK-3475) in the treatment of patients with cancer of the superficial layer of the urinary bladder and in whom treatment with BCG (Bacillus Calmette Guerin) is no longer efficacious or who do not tolerate such treatment |
| TUCH / Peter Boström | FINNBLADDER 9 | Treatment of stage Ta cancer of the urinary bladder with a high risk of relapse – blue-light cystoscopy and optimized dosage of mitomycin-C. |
| TUCH / Peter Boström | FINNBLADDER 10 | Intravesical Instillation Therapy With Bacillus Calmette-Guérin (BCG) and Sequential BCG and Electromotive Mitomycin-C (EMDA-MCC) in Patients With High-risk Non-muscle-invasive Bladder Carcinoma. |
| TUCH / Peter Boström | CA017-078 | A Phase 3, Randomized, Study of Neoadjuvant Chemotherapy Alone Versus Neoadjuvant Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Post- Surgery Therapy With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle- Invasive Bladder Cancer |
| RENAL CANCER | ||
| TUCH / Kalle Mattila | MK6482-005 | An Open-label,Randomized Phase 3 Study of MK-6482 Versus Everolimus in participants with Advanced Renal Cell Carcinoma that has progressed after prior PD-1/L1 and VEGFR Tyrosine Kinase Inhibitor Therapy |
| PROSTATE CANCER | ||
| TUCH / Peter Boström | SPCG-15 | Surgery or radiation therapy in the treatment of locally advanced prostate cancer – open, randomized clinical trial. |
| TUCH / Peter Boström | TALAPRO-2 | A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF TALAZOPARIB WITH ENZALUTAMIDE IN METASTATIC CASTRATION-RESISTANT PROSTATE CANCER |
| TUCH / Roberto Blanco | HIFU-PRO-BPH | A early phase 1 non-randomized prospective single-institutional and four arm study to determine the applicability, feasibility and safety of MRI guided transurethral HIFU ablation of prostate separately in each pre-specified group/arm |
| TUCH / Peter Boström | PRO-TULSA-PCA | Prospective Clinical Safety and Efficacy Study of Lesion-targeted MRI-guided Transurethral Ultrasound Ablation for Localized Prostate Cancer |
| TUCH / Peter Boström | ADTPSMA2 | The Effect of Androgen Deprivation Therapy on the Expression of Prostate Specific Membrane Antigen (PSMA) Evaluated With 18F-PSMA PET/CT in Treatment naïve Metastatic Prostate Cancer Patients |
| TUCH / Kalle Mattila | KEYNOTE-991 | A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK-3475) Plus Enzalutamide Plus ADT Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) |
| TUCH / Peter Boström | RHOVAC | A Phase 2, Double-Blind, Placebo Controlled Study of RV001V in Men With Biochemical Failure Following Curatively Intended Therapy For Localized Prostate Cancer |
| HEAD AND NECK CANCER | ||
|---|---|---|
| TUCH / Heikki Minn | HNLB | Genetic Profiling by Liquid Biopsy for Initial Characterization and Response Monitoring of Head and Neck Squamous Cell Carcinoma |
| HEMATOLOGICAL CANCER | ||
|---|---|---|
| TUCH / Mervi Putkonen | NMSG 23/15 | A Prospective phase 2 study to assess the minimal residual disease after ixazomib plus lenalidomide and dexamethasone (IRd) treatment for newly diagnosed transplant eligible myeloma patients |
| TUCH / Pia Ettala | Ponatinib-3001 | A Phase 3, Randomized, Open-label, Multicenter Study Comparing Ponatinib Versus Imatinib, Administered in Combination With Reduced-Intensity Chemotherapy, in Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) |
| TUCH / Maija Itälä-Remes | HaploMUDStudy | Matched Unrelated vs. Haploidentical Donor for Allogeneic Stem Cell Transplantation in Patients With Acute Leukemia With Identical GVHD Prophylaxis – A Randomized Prospective European Trial. |
| PALLIATIVE |
|---|
| GASTROINTESTINAL CANCER | ||
|---|---|---|
| Satasairaala Hospital / Kalevi Pulkkanen | SSGXXII | Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST With a High Risk for Recurrence |
| TUCH / Pirita Varpe | RESET | Laparotomy vs Laparoscopy vs Robotic vs TaTME Rectal Surgery Matched Parallel Cohort Trial for High Surgical Risk Cancer Patients, With Mid- to Low Rectal Cancer |
| MELANOMA | ||
|---|---|---|
| TUCH / Pia Vihinen | CA224-047 | A randomized, double-blind phase 2/3 study of relatlimab combined with nivolumab versus nivolumab in participants with previously untreated metastatic or unresectable melanoma |
| TUCH / Kalle Mattila | CA209-76K | A Phase 3, Randomized, Double-Blind Study of Adjuvant Immunotherapy With Nivolumab Versus Placebo After Complete Resection of Stage IIB/C Melanoma |
| TUCH / Kalle Mattila | NEKTAR | A phase 3, randomized, open-label Study of NKTR-214 combined with nivolumab versus Nivolumab in participants with previously untreated unresectable or metastatic melanoma |
| LUNG CANCER | ||
|---|---|---|
| TUCH / Maria Silvoniemi and Vaasa Central Hospital / Antti Jekunen | ASTEROID | Ablative STEreotactic RadiOtherapy wIth Durvalumab (MEDI4736). An Open Label Randomized Phase II Trial With Durvalumab Following Stereotactic Body Radiotherapy (SBRT) in Patients With Stage I Non-small Cell Lung Cancer (NSCLC) |
| TUCH / Maria Silvoniemi | DART | A study of Durvalumab, a type of immunotherapy, for treatment of patients with non-small cell lung cancer with positive or negative PD-L1 expression, following chemotherapy and radiotherapy |
| OTHER | ||
|---|---|---|
| TUCH / Kalle Mattila | PD-1 Heart | Predictive clinical, imaging and laboratory biomarkers of cardiac toxicity related to anti-programmed death (PD)-1 therapies |
| TUCH / Panu Jaakkola | MATINS | A phase I/II open-label, three part, dose-finding and separate cohort expansion trial to assess the safety, tolerability and preliminary efficacy of repeated doses of CLEVER-1 antibody FP-1305 in subjects with advanced solid tumours |
| PEDIATRIC | ||
|---|---|---|
| TUCH / Päivi Lähteenmäki | IntreALL 2010 HR | International Study for Treatment of High Risk Childhood Relapsed ALL 2010, A randomized Phase II Study Conducted by the Resistant Disease Committee of the International BFM Study Group |
| TUCH / Päivi Lähteenmäki | NOPHo-DBH AML 2012 | Research study for treatment of children and adolescents with acute myeloid leukaemia 0-18 years |
| TUCH / Päivi Lähteenmäki | ALL Together | A Treatment study protocol of the ALLTogether Consortium for children and young adults (1-45 years of age) with newly diagnosed acute lymphoblastic leukaemia (ALL), |
| TUCH / Päivi Lähteenmäki | LBL 2018 | International cooperative treatment protocol for children and adolescents with lymphoblastic lymphoma |
| TUCH / Päivi Lähteenmäki | SIOP PNET 5-MB | AN INTERNATIONAL PROSPECTIVE STUDY ON CLINICALLY STANDARD-RISK MEDULLOBLASTOMA IN CHILDREN OLDER THAN 3 TO 5 YEARS WITH LOW-RISK BIOLOGICAL PROFILE (PNET 5 MB – LR) OR AVERAGE-RISK BIOLOGICAL PROFILE |
| TUCH / Päivi Lähteenmäki | NHL 2013 | Treatment protocol of the NHL-BFM and the NOPHO study groups for mature aggressive B-cell lymphoma and leukemia in children and adolescents |
| TUCH / Miia Mokka | TEDDI | Radiotherapy Delivery in Deep Inspiration for Pediatric Patients |
| TUCH / Päivi Lähteenmäki | INFORM | INdividualized Therapy FOr Relapsed Malignancies in Childhood |
| TUCH / Päivi Lähteenmäki | rEEcur | International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma |
