Up to 20-30 % of tumors in patients with lethal castration resistant prostate cancer carry mutations in DNA repair genes. Our main goal is to understand the functional relevance of DNA repair pathways for prostate cancer and their involvement in sensitivity or resistance to current therapies. In addition, we are studying the role of factors involved in innate immune system, inflammation and metabolism in head and neck squamous cell carcinoma. Our studies using a variety of experimental model systems may open new avenues to develop clinical treatment modalities. The research group is led by Adjunct Professor Maria Sundvall, MD PhD.